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Postgraduate Studies


Institution: Clinic of Anaesthesiology reanimation and intensive care
Laboratory: Intensive Care Unite
Biochemical Lab. At Surgical Clinics
Responsible person :N. sor. Dr. Zorka Nikolova-Todorova
Field of research: Anaesthesiology
Treatment of Critically ill Patients
Methodology: Direct and indirect methods for determination of Circulation
Determination of spontaneous and mechanical ventilation
Blood analizises for metabolites, inflammation response and coagulation
Supplies: Hemodinamic and respiratory monitoring, Simens, 
Gas Blood Analyser, AVL, LI
Area of special interest for postgraduates:
Determinate fields in states of anaesthesia and in critically ill patients


Subject: Basic and applied clinical physiology of body systems

Choice subject:
Clinical Physiology of body systems in a state of anaesthesia and reanimation

1. Respiration and anaesthesia, No. of hours 10, lecturer Prof. Dr. M. Soljakova
1. 1. Mechanics of respiration and Anaesthesia
1. 2. Functional scheme of ventilation in a state of anaesthesia and terminal states
1. 3. Clinical physiology of artificial ventilation of the lungs
1. 4. Clinical physiology of hypoxia and hiperoxia
1. 5. Spyrometry, Blood gas analyses and anaesthesia-Physiological alignment of lungs and other-systems
1. 6. Functions of the lungs unrelated to gas exchange Doc. T. Trajkovska
1. 7. Physiological mechanism of airway closure-surface tension and surfactant
1. 8. Effect of anaesthetics on drainage system of the lungs
1. 9. Regulation of the respiration in a state of anaesthesia with the non-lung pathology 
1. 10. Clinical physiology of the lungs in different terminal states

2. Cardiocirculatory system and anaesthesia, No. of hours 5, lecturer Prof. Dr. O. Nojkov
2. 1. Functional scheme of disorders of circulation and anaesthesia
2. 2. Macrocirculation- Whole blood volume, mesurment, importance in anaesthesiology and reanimation
2. 3. Reology of the blood in aanaesthesia, IPPV, operation and trauma-microcirculation, perfusion of the 
Tissue and organs- reasons for disturbance
2. 4. Anaesthetic effect on circulation
2. 5. Clinical physiology of hypovolemia

3. Other systems and anaesthesia, No. of hours 10, lecturer Prof. Z Nikolova-Todorova
3. 1. Clinical physiology of renal function and anaesthesia 
3. 2. GIT in general postagressive reaction
3. 3. Physiological and biochemical changes in GIT surgery
3. 4. Clinical physiology of vomitting, regurgitation and Sy of aspiration
3. 5. Clinical physiology of disturbances in coagulation
3. 6. Clinical physiology of overtransfusion
3. 7. Clinical physiology of intravascular haemolisis
3. 8. Anaesthesiological approach to pathology of the blood
3. 9. Clinical physiology of postoperative trombembolism
3. 10. Clinical physiology of postoperative pain

4. Metabolism and hormones in a state of anaesthesia, No. of hours 5, lecturer Prof. Dr. M. Soljakova
4. 1. Oxidoreductive processes in a state of anaesthesia and terminal states
4. 2. Products of metabolism and anaesthesia-energetic balance
4. 3. Sympathoadrenal response to surgery
4. 4. Effect of anaesthesia to endocrine response
4. 5. Active polypeptides, quinines, prostaglandines


Zilber AP, Clinical physiology for anesthesiologists, Sofija, 1990
Harting V. Contemporary infusion therapy, J. A. Bern, 1992
Gamulin S. Pathophysiology, J. Zagreb, 1990
Ganong WF, Medical Physiology, PHI. London, 1993